The Board Group - Molecular Genetics

Molecular Genetics

It is now very clear that an individual's genetically determined complement of detoxication enzymes has a significant influence on their response to a variety of therapeutic drugs and environmentally derived toxins

The work of the Molecular Genetics Group is aimed at gaining a fundamental understanding of the molecular and biochemical mechanisms that underlie individual responses to such compounds. One of the major research interests of the Molecular Genetics Group is the role played by the glutathione-linked enzymes such as the glutathione transferases (GSTs) in the metabolism and detoxification of therapeutic drugs and environmentally derived carcinogens and toxins.

Data Archive

Omega GST Alignment 1See: Board et al, Journal of Biological Chemistry 275: 24798-24806

Omega GST Alignment 2 (FASTA)See: Board et al, Journal of Biological Chemistry 275: 24798-24806

Supplementary data for Omega Purification (PDF 17KB)See: Board et al, Journal of Biological Chemistry 275: 24798-24806

Chloride intracellular channel/GST alignmentSee: Dulhunty A, Gage P, Curtis S, Chelvanayagam G and Board P, Journal of Biological Chemistry 10:(in press)

Updated:  29 April 2017/Responsible Officer:  Director, JCSMR/Page Contact:  Web Manager